Design and evaluation of buccal films of isoxsuprine hydrochloride
نویسنده
چکیده
An attempt was made to formulate Buccal patches of Isoxsuprine hydrochloride, a potent and long acting vasodilator and uterine suppressant , by using Hydroxyl propyl methyl cellulose(HPMC), Polyvinyl pyrolidone K-30 (PVP K-30) and Hydroxyl ethyl cellulose (HEC). Twelve batches of buccal patches were prepared by solvent casting technique in which the best formulation was found out. The polymers HPMC, HEC, and PVP K-30 were incorporated with Isoxsuprine hydrochloride in various proportions, out of which the best formulation on the ratio (HPMC: HEC: PVPK-30-2:2:1) with the drug was determined. Prepared buccal patches were spherical, uniform in shape and white in colour. The obtained buccal films were evaluated for physicochemical characteristics, In-vitro release profile, Ex-vivo diffusion study in fresh goat cheek pouch membrane and In-vivo evaluation in rabbits. Higuchis plot studies revealed that the predominant mechanism of drug release was diffusion.
منابع مشابه
Preparation of Diphenhydramine Hydrochloride Mucoadhesive Oral Film and the Evaluation of its Pharmaceutics characteristics
Background & Objective: In recent years, mucoadhesive drug delivery systems has shown interested for prolonging the residence time of the dosage form and for providing a controlled rate of drug release. Mucoadhesive buccal films can enhance drug bioavailability by absorption through buccal mucosa and bypassing the first pass metabolism for improved therapeutic effect.. In addition, buccal films...
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